1-Methylpiperazine 98%; Plant Price and Good Quality; CAS 109-01-39

• CAS No.: 109-01-3
• Formula: C5h12n2
• EINECS: 203-639-5
• Classification: Organic Analytical Reagents
• Grade: CP
• Specific Usage: For Biological Purpose, Technical Grade, Pratical Use, Pro Analysis, For Synthesis
• Model NO.: 109-01-3
• Content: Standard
• Usage: Laboratory Reagents, Analytical Reagents, Diagnostic Reagents, Teaching Reagents
• Source: Imported Reagents
• Habit Appellation: Fine Chemicals
• Application: Industry, Scientific Research, Health, Environmental Protection, Agriculture
• Property: Organic Reagent
• Transport Package: 500ml
• Specification: 500ml
• Trademark: Jianqi
• Origin: China
• Production Capacity: 50000L/Year

Product Description

1-Methylpiperazine
1-Methylpiperazine is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP) , an antimicrotubular drug.
Bacis information
CAS	109-01-3
English alias	Piperazine, 1-methyl-;N-METHYL-PIPERAZINE;N-Methylpiperazine;PIPERAZINE,1-METHYL;4-Methylpiperazine;Cyclizine Related Compound A;1-Methyl-piperazine;METHYLPIPERAZINE
Molecular formula	C5H12N2
Molecular weight	100.162
Accurate mass	100.1
Psa	15.27
Logp	-0.2119
Numbering system
UNII
BRN number	102724
EINECS number	203-639-5
MDL number	MFCD00005966
RTECS number	TM1225000
PubChem number	24885849
Physicochemical property
Appearance and properties	Clear colorless liquid
Density	0.903g/mLat 25°C(lit.)
Boiling point	138°C(lit.)
Melting point	-6 °C
Freezing point
Flash point	108°F
Refractive index	n20/D 1.466(lit.)
Water solubility	soluble
Stability	Stable under normal temperatures and pressures.
Storage conditions	Store under Nitrogen
Safety information
RTECS number	TM1225000
Security description	S16-S26-S36/37/39-S45
Danger category code	R10; R21; R34
WGK germany	2
Dangerous goods transport code	UN 2734 8/PG 2
Customs code
Hazard category	3
Packing Grade	III
Hazard Prevention Note
Signal word
Danger mark	C
Production method and use
Production method	It is prepared by methylation of piperazine hexahydrate. Piperazine hexahydrate and hydrochloric acid were added to the reaction pot, heated to 45ºC, and the mixture of formic acid and formaldehyde was added. Add by, react at about 50ºC for 2-3h, and then heat up the reflux until carbon dioxide gas no longer escapes. Cool to 80ºC, add hydrochloric acid, heat and steam acid until dry. After slightly cooling, methanol was added, reflux was heated for 30min, and filtration was carried out while hot (the filter residue was piperazine dihydrochloride). Methanol was recovered from the filtrate to the end, and the residual liquid was added to sodium hydroxide solution to pH=14 and distilled to obtain methyl piperazine containing water. Anhydrous methylpiperazine was obtained by using benzene to heat the reflux water to the end, fractionation and collection of 132-140ºC fractions. The yield is about 50%.
Use	Used as solvent, intermediate in organic synthesis. In the pharmaceutical industry, it is used to prepare antimicrobial drugs such as meperifamycin and antipsychotic drug trifluoperazine. It is mainly used as an intermediate of ofloxacin, clozapine, Sildenafil, Torimab, Zopiclone and other drugs, and can also be used in pesticides, dyes, plastics and other industries.